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They showed that 0.1% (w/w) cuprizone supplemented to normal rodent chow did not lead to an extensive demyelination in the CC of C57BL/6 mice, while mice fed 0.3–0.5% cuprizone displayed severe weight loss and high mortality (Hiremath et al., 1998)

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The expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in lesions and normal appearing white matter of multiple sclerosis