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Deficiency of SELENOO interfered with the chondrogenic differentiation of ATDC5 cells by suppressing the expression of chondrogenic genes SOX9, COLII, and aggrecan and decreasing the activity of alkaline phosphatase 112
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Silencing GPX3 essentially nullifies the antioxidant effects of TZDs, indicating that the PPAR-dependent antioxidant effects of these drugs are mediated through GPX3 [39]
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