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In observational studies, CKD and dialysis patients who received calcitriol or synthetic vitamin D analogs (active forms of vitamin D that do not require the kidney for activation) exhibited reduced cardiovascular and all-cause mortality (Zheng 2013)

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Endothelial cells are one of the primary cell types that become senescent with aging, and multiple studies have shown endothelial cells predominant in vascular beds of multiple organs and tissues with advancing age, contributing to a variety of pathological processes associated with cardiovascular disease