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To determine the functional significance of canonical Wnt signaling in prosensory cells, these authors first used small molecule inhibitors of Wnt signaling in organotypic cultures of the embryonic (E12.5) cochlea and found that inhibition of Wnt signaling results in decreased proliferation of prosensory cells (Jacques et al., 2012)

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In addition to genetics, other hyperuricaemia/gout risk factors include: 1, 5, 6 Older age Male sex Obesity Cardio-metabolic co-morbidities, particularly CKD, hypertension and hyperlipidaemia Use of medicines that influence urate production, reabsorption or excretion, e.g