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Apart from that, the activation of Nrf2 by chlorogenic acid restores mitochondrial ion protein homologue (Lon) protein expression and reduces mitochondrial HSP60 release, attenuating APAP-induced inflammatory liver injury (Hu et al., 2020)
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The details of the PI3K-AKT-mTOR signaling network and its targeting were previously and extensively described by other authors [193,194,195,196,197,198] and will not be discussed here in detail
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