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146, 147, 148 Although the identity of the cytoplasmic components that account for the extranuclear toxicity of CDDP has only recently begun to emerge, these molecules as well as the enzymatic systems that regulate their preservation/turnover may also be involved in the development of on-target CDDP resistance

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Also, it should be recalled that four major events (vascular constriction, loose platelet plug, fibrin mesh to insure stability of platelet plug, and dissolution of the clot) are implicated in the wound healing process and occur in a set order following the loss of vascular integrity[3]

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