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Furthermore, kinetic studies in healthy nondiabetic human subjects studied under pancreatic clamp conditions demonstrated that sitagliptin reduced the production rate of apoB48 lipoproteins, with no effect noted on the production or clearance of ApoB100 (203)
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This hypothesis is supported by elevations in brain HGF levels measured in several degenerative diseases including amyotrophic lateral sclerosis, multiple sclerosis, Parkinson’s disease, spinal cord injury and AD [78-82]
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