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In one trial that did not find preoperative coenzyme Q 10 supplementation to be of benefit, patients were treated with 600 mg of coenzyme Q 10 12 hours prior to surgery (41), suggesting that preoperative coenzyme Q 10 treatment may need to commence at least one week prior to CABG surgery to improve surgical outcomes
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Furthermore, through the accumulation of ROS, decreased NAD + levels cause damage to mitochondrial DNA and nuclear DNA (Cohen, 2020)
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