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In contrast, when bound to transcobalamin II, the half-life is significantly shorter, approximately 1.5 hours, although the final plasma curves for both forms yield similar half-life values of around 9.3 to 9.8 days due to the rapid reappearance of the radiocobalt label bound to transcobalamin I

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This has led to growing interest in triple agonist therapies for: obesity, metabolic syndrome, insulin resistance, fatty liver disease, and body composition management