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Retrochalcones are recognized for their photo reactivity due to α,β unsaturation
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Of note, unlike carbonyl scavengers that target only a single line of defense, NRF2 regulates genes across all three defense lines, including those encoding antioxidant enzymes, RLA-detoxifying enzymes, and components of the 20S proteasome and lysosome, such as Proteasome Subunit β-Type 5 (PSMB5), PA28αβ, and Sequestosome-1 (p62) (36, 216–223)
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