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Several pro-oxidative enzymes, including nicotinamide adenine dinucleotide phosphate oxidase (NOX), cytochrome P450 (CYP450), and xanthine oxidase (XO), have been identified in the lens and contribute to elevated ROS levels, which are associated with lens opacification [105,106,107]

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In addition to being widespread, endothelial cells are one of the first cell types to become senescent with advancing age [214] , and the cellular senescence markers p16 and p21 increase in the vasculature to a greater extent than any other tissue in both natural aging and progeroid mouse models [12]