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Mechanistic analyses have demonstrated the core process involving the METTL1-mediated serine and arginine rich splicing factor 9 (SRSF9)/nuclear factor of activated T-cells, cytoplasmic 4 (NFATc4) signaling axis, where m7G modification enhances the RNA stability of splicing factor SRSF9, facilitating the alternative splicing of NFATc4 and nuclear translocation, thereby activating the calcineurin pathway
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