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The observation that the loss of FH, a bona fide tumour suppressor gene 22 , could lead to senescence, although counterintuitive, suggests that the role of FH in tumorigenesis is complex and might involve secondary oncogenic alterations to overcome senescence
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Stockwell’s lab in Columbia University report that the gene expression of CHAC1, PTGS2, SLC7A11 , and ACSL4 was induced during ferroptosis, and their upregulation detected by qPCR can be regarded as an indicator of ferroptosis (Dixon, Patel et al., 2014, Stockwell, 2022)
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