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However, further studies are currently evaluating the safety and efficacy of tariquidar in combination with a variety of chemotherapeutic compounds in patients with solid tumors, including brain malignancies ( In general, little toxicity to the central nervous system has been reported in patients treated with P-gp inhibitors, even in those treated with neurotoxic chemotherapeutic compounds (Gottesman et al., 2002)
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[DOI] [PubMed] [Google Scholar] 68.Yen BL, Yen ML, Hsu PJ, Liu KJ, Wang CJ, Bai CH, et al
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