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igf-1 lr3 bone growth study Insulin-like factor-1 in articular cartilage repair for osteoarthritis treatment | Arthritis Research & Therapy Brand_Active White
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Activation of HO-1 promotes the expression of the System Xc- system and accelerates cystine/glutamate transport, leading to the scavenging of accumulated lipid peroxides and the inhibition of oxidative stress, thereby reducing cellular sensitivity to ferroptosis
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Furthermore, female mice display impairments in estrous cycling, suggesting that signaling by ObRb Y1077 plays only a modest role in the control of metabolism by leptin, while it may link body adiposity to the reproductive axis (113)
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