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6 Challenges and prospects 6.1 The complex interaction between bioavailability, metabolism, and intestinal pathology The clinical application of polyphenols is severely limited by their inherent characteristics, including chemical instability, low absorption rate in the gastrointestinal tract, and extensive and rapid metabolism by host enzymes and gut microbiota, resulting in generally low bioavailability of most polyphenols and significant individual differences
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As for the relevant antioxidants, it has not been elaborated and speculated that it might be the synergy of betalains and other compounds
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