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Supplementation with oleuropein aglycone, another polyphenol in olive oil, improved memory and attenuated Aβ plaque area,soluble Aβ40 and Aβ42, and astrocyte activation in the brains of TgCRND8 AD mice, an AD mouse model that overexpresses human APP, encodes the Swedish and Indiana mutations and develops substantial Aβ plaque buildup by 3 months of age 79
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