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The levels and secretion of leptin and adiponectin were decreased by sodium arsenite alone (1 µM for 72 h in vitro ) or in combination with palmitate (200 µM) when the treatment occurred during adipogenic differentiation of 3T3-L1 cells, but not by treating fully differentiated 3T3-L1 adipocytes, indicating that the effect depends on the differentiation window of the adipocyte lineage at which exposure began (41)