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Tendon is composed of cells (tendon fibroblasts) and extracellular matrix, which contains mostly type I collagen, type III collagen and glycoproteins

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Mechanisms of OR desensitization OR phosphorylation Numerous studies have been carried out to demonstrate the role of OR phosphorylation in desensitization by using chemical inhibitors of kinases, in vitro or in vivo knock-out (KO) of kinases using siRNA or transgenic mice, over-expression of dominant negative mutants of kinases, amino acid substitution or truncation on OR