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The intricate interplay between OS and neuroinflammation constitutes a fundamental driver of disease progression in MS, as well as in other autoimmune and neurodegenerative disorders of the nervous system ( As a master transcriptional regulator of cytoprotective responses, NRF2 plays a critical role in mediating neuroprotection through its coordination of antioxidant defenses, regulation of inflammatory signaling, and maintenance of cellular redox homeostasis (Tonelli et al., 2018)
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