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human relevance for cagrilintide specifically has not been established History of pancreatitis — amylin analogs affect gastrointestinal motility, and the class-level precautionary approach applied to incretin-class compounds warrants extension here Pregnancy or breastfeeding — no reproductive or developmental toxicology data in humans Severe gastroparesis — cagrilintide's mechanism includes slowing gastric emptying, creating a theoretical risk in pre-existing gastroparesis Hypersensitivity to cagrilintide or any component of its formulation Which biomarkers are relevant if you are exploring metabolic health