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Noting the safety and clinical experience with its individual constituents, ARINA-1 has been studied in a phase I clinical trial in patients with bilateral lung transplant, with a phase II clinical trial currently being planned for patients with bilateral lung transplant who have early bronchiolitis obliterans syndrome

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(2017), vitamin E supplementation alone impaired sustained attention in individuals with high baseline PUFA levels, likely due to excessive increases in serum α-tocopherol which may have acted as a pro-oxidant in an already lipid-rich environment, thereby disrupting redox balance and contributing to cognitive decline [59]