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dihexa cognitive study 2019 Chronic hypoxia leads to impairment by promoting HIF-2α-mediated ceramide catabolism and alpha-synuclein hyperphosphorylation structural-binding-peptides
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Following the HGF binding, the kinase activity of MET is switched on by receptor dimerization and trans- phosphorylation of two catalytic tyrosine residues (Tyr1234 and Tyr1235) within the kinase activation loop, then by phosphorylation of two additional docking tyrosine kinases in the C-terminal tail (Tyr1349 and Tyr1356)
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