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133 Importantly, S6K1 depletion, which is a component of mTOR signaling, also leads to a prolonged lifespan in mice

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GLP-1R Expression and Direct Cutaneous Effects Emerging evidence suggests that GLP-1R is expressed in several components of the skin, as illustrated in Figure 2, indicating that GLP-1 signalling may exert direct local effects within the cutaneous microenvironment [10,11,37,38]