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additionally, a rat model of ligature-induced periodontitis was shown to induce systemic inflammation and microglial activation, with inflammatory factors, IL-1β, IL-6, IL-8, and IL-21, elevated in the peripheral blood and brain (Hu et al., 2021)
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The PHES consisted of five tests: the digit symbol test, number connection test (NCT)-A, NCT-B, serial dotting, and line tracing
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