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Why L-Citrulline Supplementation Outperforms L-Arginine Despite L-arginine's direct role in NO production, L-citrulline offers several advantages as a supplement: Superior Bioavailability - Oral L-arginine undergoes extensive breakdown in the intestines and liver, with approximately 40% degraded during first-pass metabolism
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It induces an immune reaction in the pregnant mother’s body, resulting in further inflammation and oxidative stress in the placenta and fetal brain
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