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Moreover, IGF1R activated by IGF-1 plays a role in epidermal growth factor receptor (EGFR)-mediated primary or secondary resistance to colorectal cancer by upregulating the PI3K/AKT signaling pathway (16)
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The interaction of LPS with Toll-like receptor 4 (TLR4) on Kupffer cells triggers the production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), activating a sterile immune response that contributes to disease progression from steatosis to steatohepatitis [61]
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