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The blood–brain barrier (BBB) ingests iron through transferrin on brain capillary endothelial cells, and then transports it into the cerebral cytoplasm through astrocytes or through divalent cation-binding protein (DMT1) and maintains iron an approximately saturated steady state in the brain (Guiney et al., 2017
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230 In addition, there are many other proteins containing jumonji domain, for instance, similar to JARID1 family, although JARID2 does not have demethylase activity, its expression inhibits the formation of differentiation markers, and regulates keratinocyte differentiation genes
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