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A 2023 systematic review of 15 RCTs found that 11 out of 15 showed net positive effects on pain compared to control conditions, 12 out of 15 showed functional improvement versus baseline, and cartilage protection or repair was demonstrated in 18 out of 21 clinical studies
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Under these conditions, whole cell acetyl-CoA abundance was similar between genotypes (Supplemental Figure 5B)
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