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Despite increased levels of NO have been involved in degenerative events, NO is also a well-known small molecule that acts as a second messenger in cellular signaling and in a large variety of diverse physiological processes, including neurotransmission, vascular relaxation, blood pressure regulation, defense mechanisms, and immune regulation [51]
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However, the findings across rodent studies have been inconsistent, with some reporting increased methylation, while others have observed reductions, even when using similar selenium dietary regimens
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