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Its efficacy is lower than that of injected Botox, but as researchers note, this is to be expected.22 Similar results were found in a small 2013 study, with the “total anti-wrinkle efficacy” of the Argireline treatment group being 48.9% compared to 0% in the placebo group.23 However, a more recent 2023 study investigating the effects of a serum containing Argireline and hyaluronic acid found the results to be “not statistically significant.”24 This means that more research is needed before claims that Argireline is a true alternative to Botox can be confirmed or denied
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