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B12 Shot vs. B12 Pills: How Many Pills Equal a Shot? - The IV Lounge
Agrawal and colleagues, reviewing nose-to-brain delivery in 2018, describe this as the principal reason the route attracted attention for centrally acting compounds: material deposited on the olfactory epithelium can reach the brain while bypassing both first-pass metabolism and the barrier that excludes most peptides from the CNS
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Conversely, pernicious anemia resulting from vitamin B12 deficiency may cause infertility or poor pregnancy outcomes
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