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Remarkably, malic enzyme 1 (ME1), which yields pyruvate from malate and converts NADP + to reduced nicotinamide adenine dinucleotide phosphate (NADPH), might reduce the accumulation of ROS and redox-active iron, hence resisting ferroptosis induced by inhibition of SLC7A11 [43]
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However, the clinical studies reported to date lack head-to-head comparisons of ACEis for the treatment of the specific pain conditions discussed in this review
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