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Regulation of BACH1 Stabilization At high heme concentration, heme directly binds to BACH1 via six cysteine‐proline motifs located in an intrinsically disordered region, and heme binding induces a global conformational change in BACH1's heme‐binding region, [ 20 ‐ 22 ] thus inactivating BACH1 DNA‐binding activity, [ 23 ] and facilitating BACH1's nuclear export and degradation
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