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Even though 2-AAPA did not elevate the GSSG/GSH ratio above the effects of ET at the 8 h time point (see Figure 4D), it is likely that the combination of 2-AAPA and ET would elevate the GSSG/GSH ratio at earlier time points compared with ET alone, thus diminishing the early transcriptional induction of UPR targets, which would still be evident when mRNAs were collected at 8 h

have not been evaluated by the FDA and are not intended to diagnose