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A1 astrocytes facilitate glial scar formation and inhibit axonal growth via glial fibrillary acidic protein, chondroitin sulfate proteoglycan, and transforming growth factor-β (TGF-β), while A2 astrocytes promote axonal growth through platelet-derived growth factor and play a critical role in vascular remodeling ( 2.1.2 Recruitment of immune cells at the periphery Following a stroke, there is a significant increase in the release of peripheral inflammatory markers
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Notably, the three-dimensional structure indicates that OsDHAR contains a broad, uncharged cleft between the α2-helix and the α3-helix as the putative binding site for non-native protein folding intermediates for its chaperone-like activity
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