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L-GSH and SP were applied to each well alone or in combination at the following concentrations: no L-GSH, 40 mM L-GSH, 80 mM L-GSH, no SP, 5 ng/mL SP, and 10 ng/mL SP

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Immunosuppressive cells within the tumor microenvironment disrupt T cell activation and proliferation by increasing the expression of immunosuppressive receptors such as PD-1 and CTLA-4 and by releasing immunosuppressive cytokines like IL-6, IL-10, TGFβ, and VEGF (Mariathasan et al., 2018