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BBB dysfunction is considered a key mechanism through which peripheral inflammation contributes to CNS pathology in ASD, allowing inflammatory molecules and immune cells to infiltrate neural tissue and exacerbate neuroinflammation (Candelario-Jalil et al., 2022
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Individuals with a known hypersensitivity or allergy to vitamin B₁₂ (cobalamin) or any other component of the injection must not use Lipo-B, as allergic reactions could be severe
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