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While direct measurement of methemoglobin concentration will clinch the diagnosis, oxygen saturation differential between pulse oximetry reading and arterial blood gas measurement should alert the transplant physician
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The common allele is cytoprotective against the toxic effects of chemotherapeutics, whereas the functionally less competent allele is thought to increase the toxicity of anticancerogenic drugs in patients with this gene variant due to decreased metabolic activity of impaired enzyme
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