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Furthermore, the production of ROS is linked to impaired mitochondrial function, which subsequently triggers the p53/p21 Cip1 signaling pathway (Takemura et al., 2020)
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Two noncanonical c-Myc binding sites (CACATG, E box) are present in the human GCLC promoter at −559/−554 and −500/−495 and together with ARE4, are responsible for H 2 O 2 -induced GCLC promoter activity [120]
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