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Clostridium butyricum , the main producer of butyrate in the human gut, reduces the occurrence of CRC by downregulating the oncogenic WNT signaling pathway (156)
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Another study showed that in JHU-083-treated cancer cell allograft models, an increase in nutrient levels and oxygen and a decrease in the acidity of the TME resulted in T-cell-mediated tumor suppression 145 , whereas another study demonstrated the effects of JHU-083 on myeloid-derived suppressor cells (MDSCs) and TAMs 150
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