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The source-to-sink transition of ROS relies on chain reactions depending on the redox potential of the elements (Pospíšil et al., 2019

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This imbalance leads to widespread oxidative damage, including lipid peroxidation, which destabilizes neuronal membranes, protein oxidation, which results in the accumulation of toxic aggregates, and DNA damage, which triggers cell-death pathways [35,65,66,67,68,69,70] (Figure 1)