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Additionally, evidence indicates that E₂ can also directly enhance the activity of the electron transport chain (ETC) by binding to ERβ within mitochondria, thereby improving cellular respiration and ATP production [48,49]
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Ishikawa et al., Heme oxygenase-1 and other antioxidant genes protect against atherosclerosis The importance of HO-1 expression in the protection against human atherosclerotic lesions has been emphasized by various genetic population studies, which have shown that a GT length polymorphism in the promoter region of the human HO-1 gene is related to susceptibility for atherosclerosis
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