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Seahorse oxymetry Cells were plated on XF96 culture plates (20,000 cells/well) in complete NB medium

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Indeed, the SG of SS patients displays overactivity of CD8 + T cells ( + T cells are known to exert cytotoxic functions, which eliminate the infection via the Fas/Fas ligand (FasL) pathway, leading to the large-scale cell apoptosis and tissue damage ( Figure 1 ), including acini injury ( + T cells accumulate in an aberrant manner and release cytotoxic-related molecules, including IFN-γ, TNF-α, perforin, and granzyme B ( + T cells may owe to CXCR3-mediated chemotaxis, which drives the CD8 + T cells’ migration into the inflamed SG in patients with pSS ( CD8 + T cells with tissue-resident memory (TRM) signature have been recently highlighted in the contribution to tissue fibrosis in aged mice ( + CD9 + T cells constitute the tissue-resident memory population infiltrated in SG biopsies of pSS patients ( + CD103 + CD69 + TRM was identified as being involved in sialadenitis, with a significant increase in IFN-γ production, in which CD69 and CD103 are the tissue residence markers ( + -specific TRM and SG fibrosis