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Class III enzymes, known as sirtuins, require NAD+ cofactors and include SIRTs 1-7
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Their work, based on a literature search spanning 2000 to 2025, highlights the significant impact of CYP2D6 and CYP2C19 variations on drug metabolism and tolerability, and emphasizes the crucial role of ethnicity and sex-based differences in pharmacogenetic influences on antidepressant response
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