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Introduction Parkinson’s disease (PD) is the fastest growing neurodegenerative disorder, affecting more than 8.5 million people ( SNCA , LRRK2 , VPS35 ) or recessive ( PRKN , PINK1 , PARK7 ) PD-related genes, account for less than 10% of Mendelian cases ( GBA1 gene has emerged as a common risk factor for PD, estimated to occur in about 4–12% of PD patients ( MAPT ) gene has been also associated with increased risk of PD ( MAPT H1 sub-haplotype (H1c) has been strongly linked with progressive supranuclear palsy (PSP
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