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Anacardium occidentale also showed the active participation of AsA-GSH cycle by integrative responses of both non-enzymatic and enzymatic antioxidants for drought-induced excess ROS regulation, where the higher accumulation of AsA and GSH, along with APX activity, coordinately reduced the overproduced H 2 O 2 [112]

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In addition, studies have found that TMAO increases NADPH oxidase activity, induces the production of ROS, and an increase in ROS can promote the translocation of NF-κB from the cytoplasm to the nucleus (68)

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