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All these concepts, such as early hyperdopaminergic or late hypodopaminergic hypotheses, refer to quantitative making qualitative changes in neurotransmitter functioning and are finally related to cumulative damage to the CNS [29,60,100,108]

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To examine the functional consequences of elevated DDX3X, we overexpressed DDX3X and its Y-linked homolog DDX3Y in cultured female and male neurons and performed RNA sequencing to define transcriptional responses