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491 This approach combining AAV-mediated guide RNA delivery with LNP-mediated Cas9 mRNA expression showed editing efficiencies near 17%, which is comparable to dual-AAV systems but offers a safer, transient expression profile

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Also, antioxidants that are modified to go inside the mitochondria and act as mitochondrial ROS scavengers or neurohormones that have antioxidant properties (e.g., melatonin) were tested in stroke patients that received standard therapy [60]