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4.2 Indirect effects of music on the “PFC-Hip-Amy” circuitry The “PFC-Hip-Amy” circuitry is engaged with monoamine dysregulation, the glutamatergic system, the gut-brain axis, and the neuroinflammatory immune response, all of which significantly impact the development and healing processes of NPDs (Sanacora et al., 2022)

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Glucocorticoids such as prednisone are used to treat difficult cases that do not respond adequately to first-line pharmacologic or other treatments